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Investigating the effect of probiotics on SIRS after PCNL

Investigating the effect of probiotics on SIRS after PCNL and inflammatory factors of patients after surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250925067361N1
Enrollment
134
Registered
2026-01-26
Start date
2026-01-30
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PCNL Surgery. Calculus of kidney

Interventions

Intervention 1: Intervention group: Participants taking the probiotic drug Perazocap from Tehran Darou Company, which contains 6 components including the probiotics Lactobacillus and Bifidobacterium,

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Stones larger than 2 cm and less than 3 cm in the lower or middle calyceal Patients for whom only one access was taken during surgery The duration of the surgery was up to 1.5 hours and did not require intraoperative Pac cell injection Also, there was no evidence of pyelocaliectasis greater than 10 mm, which is considered pyelocaliectasis

Exclusion criteria

Exclusion criteria: Patients with tumors, diabetes, those taking oral immunosuppressive drugs Patients with horseshoe kidney, polycystic kidney or ureteropelvic junction stenosis, those whose heart rate is more than 90 beats per minute before surgery Patients with heart or kidney failure, preoperative fever treated with antibiotics, second PCNL, one PCNL in combination with another manipulation in one operation.

Design outcomes

Primary

MeasureTime frame
Systemic inflammatory response - white blood cell count - C-reactive protein - neutrophil to lymphocyte ratio. Timepoint: 7 days before the intervention and the day after the operation until discharge. Method of measurement: laboratory , vital sign.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad moein Shafaei

Tehran University of Medical Sciences

moeinshafaei@gmail.com+98 21 7790 9837

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026