Cancer-related cognitive impairment.
Conditions
Interventions
Intervention 1: First intervention: Memory and attention adaptation training(MAAT). Sessions will be conducted according to the clinical manual authored by Robert J. Ferguson and Karen L. Gillock. Th
Sponsors
Institute for Cognitive Science Studies
Eligibility
Sex/Gender
Female
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: The participant must be fluent in Persian. The participant must have a minimum educational qualification of a diploma. The participant must be a female breast cancer survivor. The participant must be between 30 and 55 years old. At least one year has passed since the end of surgery, chemotherapy, and radiotherapy. The participant is receiving oral hormonal therapy (tamoxifen or letrozole). The participant complains of persistent cognitive problems related to the cancer or its treatments. The participant has given informed consent to participate in the clinical trial. Breast cancer recurrence has been ruled out by an oncologist.
Exclusion criteria
Exclusion criteria: Participants must not have any serious systemic illness or unstable medical condition that could interfere with their ability to participate in the cognitive rehabilitation intervention or complete the study procedures. Participants must not have a current diagnosis of any active neurological disorder, nor a history of significant head trauma associated with persistent neurological deficits or structural brain abnormalities. Participants must not have any untreated major psychiatric disorder, as defined by DSM-5 (e.g., Major Depressive Disorder). The use of psychiatric medications, such as antidepressants, prescribed for previously diagnosed depression is permitted, provided the dosage has been stable for at least three months prior to enrollment. Participants must not have a history of alcohol abuse, substance misuse, or dependency within the past two years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Memory. Timepoint: pre-intervention, post-intervention, 3 month follow-up. Method of measurement: CANTAB.;Attention. Timepoint: Pre-intervention, Post-intervention, 3 month follow-up. Method of measurement: CANTAB.;Quality of life. Timepoint: Pre-intervention, Post-intervention, 3 month follow-up. Method of measurement: Questionaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective cognitive performance. Timepoint: Pre-intervention, Post-intervention, 3-month follow-up. Method of measurement: FACT-COG Questionaire.;Processing speed. Timepoint: Pre-intervention, Post-intervention, 3-month follow-up. Method of measurement: The Cambridge Neuropsychological Test Automated Battery (CANTAB). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Bidsoukhteh Nezamabadi
Institute for Cognitive Science Studies
Outcome results
None listed