Total Knee Arthroplasty.
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will receive oral dexamethasone (8 mg) administered in three doses: one dose before surgery (up to 60 minutes before surgery). Two doses afte
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: primary total knee replacement surgery. Written consent to participate in the study General conditions suitable for surgery and ability to follow the next stages of the study
Exclusion criteria
Exclusion criteria: Allergy to dexamethasone or other corticosteroids Use of corticosteroid medications in the past week Uncontrolled diabetes (HbA1c > 7.5) or renal failure (GFR < 60). Advanced liver failure Pregnancy or breastfeeding. History of active infectious diseases or immunodeficiency Chronic use of opioids or chronic pain medications Uncontrolled chronic diseases, such as cardiovascular disease or severe osteoporosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: At 6, 12, 24, and 48 hours after surgery. Method of measurement: visual analoge scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee Rang of Motion. Timepoint: 48 hours after surgery. Method of measurement: Examination.;Muscle Strength. Timepoint: 48 hours after surgery. Method of measurement: Examination.;Amount of painkiller consumption. Timepoint: 48 hours after surgery. Method of measurement: Frequency and Dosage.;Side Effects. Timepoint: 48 hours after surgery. Method of measurement: Examination.;Evaluation of knee function. Timepoint: One Week After Surgery. Method of measurement: Knee Injury and Osteoarthritis Outcome Score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEhsan Gholami
Iran University of Medical Sciences
Outcome results
None listed