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Evaluation of the Therapeutic Effects of a Herbal Cream Prepared from Tea tree, Sour tea, Chamomile and Cinnamon plant extracts for the Treatment of Genital Warts Compared to Podophyllin Treatment, Cryotherapy, and Imiquimod

Evaluation of the Therapeutic Effects of a Herbal Cream Prepared from Tea tree, Sour tea, Chamomile and Cinnamon plant extracts for the Treatment of Genital Warts Compared to Podophyllin Treatment, Cryotherapy, and Imiquimod

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250916067270N1
Enrollment
200
Registered
2025-12-01
Start date
2025-12-22
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

genital warts. Anogenital (venereal) warts

Interventions

Intervention 1: Intervention group 1: Forty patients (20 women and 20 men) will topically apply a herbal cream containing extracts of cinnamon 0.1%, bergamot 0.1%, thyme 0.2%, hibiscus 0.1%, flaxseed

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adults 18+ with at least two visible external genital warts. volunteer must be in good general health, as confirmed by medical history. The volunteer must be able to read, sign, and understand the informed consent. The volunteer must be willing to forgo any other treatment for their EGW lesions. The volunteer is capable of participating in the study as an outpatient, making frequent visits to the study center during the treatment and follow-up periods, and adhering to all study requirements, including concurrent medication use and other treatment restrictions. negative pregnancy

Exclusion criteria

Exclusion criteria: Includes any evidence of genital herpes or any other current and/or recurrent or uncontrolled genital infection, including human immunodeficiency virus (HIV), hepatitis B, or hepatitis Medically unstable condition as diagnosed by the clinical investigator. Regarding any skin condition in the treatment area that may be aggravated by the proposed treatment or interfere with the assessment of EGW lesions. Women who are pregnant, lactating, or planning to become pregnant during the study period People with skin diseases that may interact with the cream studied, or with internal warts (vaginal or rectal) that require treatment. Participants who, within the 30 days prior to the start of the study treatment, have used any prescribed topical medications in the study area.

Design outcomes

Primary

MeasureTime frame
Complete clearance of genital warts. Timepoint: Weekly. Method of measurement: Observation and counting.;Reduction in lesion size or number. Timepoint: weekly. Method of measurement: Observation and counting.;Time required for clearance. Timepoint: monthly. Method of measurement: Observation.;Recurrence of wart. Timepoint: monthly. Method of measurement: Observation.;Side effects. Timepoint: weekly. Method of measurement: Observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Alimardn

Arak University of Medical Sciences

z_alimardan@yahoo.com+98 86 3368 2210

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026