The effect of platelet-rich plasma (PRP) on graft success in fat patch tympanoplasty

Evaluation of Graft Success in Fat Patch Tympanoplasty With and Without Platelet-Rich Plasma (PRP) In patients between the ages of 18 and 60 with a perforated eardrum who are candidates for fat patch tympanoplasty.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250915067263N1

Enrollment

Registered

2025-09-26

Start date

2025-09-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tympanic Membrane Perforation. Perforation of tympanic membrane

Interventions

Intervention 1: Intervention group: Includes patients aged 18 to 60 years with a tympanic membrane perforation of less than 25% who are candidates for tympanoplasty with fat graft with platelet-rich p

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 60 years with a perforated eardrum due to infection or trauma The size of the perforation is less than 25% of the eardrum surface Stable middle ear status (no active infection at the time of surgery) Willingness to participate in the study and signing an informed consent form

Exclusion criteria

Exclusion criteria: Patients under 18 years of age or over 60 years of age with a perforated eardrum caused by infection or trauma The size of the perforation greater than 25% of the eardrum surface (not candidates for tympanoplasty with fat graft) Unstable middle ear condition (active infection at the time of surgery) Unwillingness to participate in the study and sign the informed consent form

Design outcomes

Primary

Measure	Time frame
Success rate of eardrum perforation closure. Timepoint: One day before surgery and then at weeks 4, 8, and 12 after surgery. Method of measurement: Examination with otoscopy and tympanometry.;Duration of complete eardrum repair. Timepoint: One day before surgery and then at weeks 4, 8, and 12 after surgery. Method of measurement: Examination with otoscopy and tympanometry.;Postoperative hearing thresholds. Timepoint: One day before surgery and then at weeks 4, 8, and 12 after surgery. Method of measurement: Examination with audiometry.;Occurrence of surgical complications (infection, graft degradation, residual defect). Timepoint: One day before surgery and then at weeks 1, 4, 8, and 12 after surgery. Method of measurement: Examination with clinical examination, otoscopy, tympanometry, and audiometry.;Need for revision surgery. Timepoint: 6 to 12 months after initial surgery. Method of measurement: Examination with otoscopy, tympanometry, and audiometry.	—

Measure

Time frame

Success rate of eardrum perforation closure. Timepoint: One day before surgery and then at weeks 4, 8, and 12 after surgery. Method of measurement: Examination with otoscopy and tympanometry.;Duration of complete eardrum repair. Timepoint: One day before surgery and then at weeks 4, 8, and 12 after surgery. Method of measurement: Examination with otoscopy and tympanometry.;Postoperative hearing thresholds. Timepoint: One day before surgery and then at weeks 4, 8, and 12 after surgery. Method of measurement: Examination with audiometry.;Occurrence of surgical complications (infection, graft degradation, residual defect). Timepoint: One day before surgery and then at weeks 1, 4, 8, and 12 after surgery. Method of measurement: Examination with clinical examination, otoscopy, tympanometry, and audiometry.;Need for revision surgery. Timepoint: 6 to 12 months after initial surgery. Method of measurement: Examination with otoscopy, tympanometry, and audiometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Jabbari Joushin

Shahid Beheshti University of Medical Sciences

mo.jabbari20@yahoo.com+98 21 2303 1443

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026