Coronary artery disease. Ischaemic heart diseases
Conditions
Interventions
Intervention 1: In the intervention group, 1 mg/kg diphenhydramine will be administered intravenously. The following drugs will be used for anesthesia: 1-2 mg/kg propofol, 6-8 µg/kg fentanyl, 0.05-0.0
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adult patients (aged 18-80 years) Patients with American Society of Anesthesiologists (ASA) physical status I-III Patients who have informed consent to participate in the study Patients admitted to Tehran Heart Center Hospital
Exclusion criteria
Exclusion criteria: Patients with known hypersensitivity to diphenhydramine or other antihistamines Pregnant or breastfeeding women Patients with significant hepatic or renal dysfunction. Patients on medications that may interact with diphenhydramine (e.g., monoamine oxidase inhibitors)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normal and acceptable values ??are systolic blood pressure =140 mmHg or diastolic blood pressure =90 mmHg. Timepoint: Patients' blood pressure is recorded at 20 and 60 minutes of surgery. Blood pressure is also measured and recorded at 1, 5, 12, and 24 hours after surgery. Method of measurement: Blood pressure is measured using an arteriole, which is fixed to the patient before the procedure.;Heart rate, the normal range of which is 60 to 100 beats per minute. Timepoint: Blood pressure is recorded at 20 and 60 minutes of surgery. Blood pressure is measured and recorded at 1, 5, 12, and 24 hours after surgery. Method of measurement: It is measured by the section monitoring device.;Oxygen saturation level (SpO2), the standard range is between 94 and 99 percent. Timepoint: It is measured and recorded during the 20th and 60th minutes of surgery, as well as at 1, 5, 12, and 24 hours after surgery. Method of measurement: It is measured with a pulse oximetry device.;Normal values ??for the bispectral index (BIS) are 40 to 60. Timepoint: Once immediately after the injection of anesthetic maintenance drugs. Method of measurement: With a dual-spectrum index measuring device in the operating room. | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of hospitalization. Timepoint: 3 to 4 days after surgery. Method of measurement: Check the discharge order by the attending physician. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactafzal shamsi
Tehran University of Medical Sciences
Outcome results
None listed