Comparison of the effect of using iodine-impregnated surgical drape with conventional sterile drape on microbial load and surgical site infection

Comparison of the effect of using iodine-impregnated surgical drape with conventional sterile drape on microbial load and surgical site infection following Total Knee Arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250910067209N1

Enrollment

Registered

2026-02-27

Start date

2025-09-23

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty.

Interventions

Intervention 1: Intervention group: Iodine-impregnated sterile drape (45 × 60 cm) containing an active iodine film. Intervention 2: Control group: Conventional sterile drape (40 × 60 cm) without an io

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Candidates for total knee arthroplasty

Exclusion criteria

Exclusion criteria: Presence of any type of diabetes mellitus Presence of a local infection near the surgical site Presence of systemic infection Presence of immunodeficiency disorders Presence of malignant diseases History of radiotherapy or chemotherapy Use of immunosuppressive medications History of surgery on the ipsilateral knee Known allergy to povidone-iodine Presence of skin rash or dermatological lesions at the surgical site Use of antibiotics within one month prior to hospital admission

Design outcomes

Primary

Measure	Time frame
Microbial load at the surgical site (CFU/mL) after the use of iodine-impregnated and conventional sterile drapes. Timepoint: After 24 hours of incubation, the number of colonies grown on each 8-cm blood agar plate was counted and recorded in the microbial count form. Method of measurement: Colony counting was performed manually by placing the inverted plate on a white gridded surface and counting the colonies by marking the grid squares.;Incidence of surgical site infection following the use of iodine-impregnated and conventional sterile drapes. Timepoint: At 24 hours and 30 days after surgery. Method of measurement: Using the surgical site infection checklist.	—

Measure

Time frame

Microbial load at the surgical site (CFU/mL) after the use of iodine-impregnated and conventional sterile drapes. Timepoint: After 24 hours of incubation, the number of colonies grown on each 8-cm blood agar plate was counted and recorded in the microbial count form. Method of measurement: Colony counting was performed manually by placing the inverted plate on a white gridded surface and counting the colonies by marking the grid squares.;Incidence of surgical site infection following the use of iodine-impregnated and conventional sterile drapes. Timepoint: At 24 hours and 30 days after surgery. Method of measurement: Using the surgical site infection checklist.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Faddaye Hosseini Maleki

Iran University of Medical Sciences

info@iums.ac.ir+98 21 86709

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026