platin Base chemotherapy Regimes Induced neuropathy. Drug-induced polyneuropathy
Conditions
Interventions
Intervention 1: Intervention group: Receiving Deluxetine. Intervention 2: Control group: Receiving Placebo.
Sponsors
Artesh University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Over 18 years old Confirmation of cancer diagnosis Written consent from the patient No history of duloxetine use The chemotherapy regimen contains platinum.
Exclusion criteria
Exclusion criteria: The participant's unwillingness to start or continue cooperation Severe side effects from taking duloxetine, such as severe nausea, excessive drowsiness, increased blood pressure, or psychotic symptoms. Intolerance to medication or failure to take it regularly as prescribed by the doctor, including frequent forgetting to take it or arbitrarily stopping the medication. A change in the patient's clinical condition that makes it impossible to continue the study, such as prolonged hospitalization, change in chemotherapy regimen, or the development of new diseases. Failure to attend follow-up sessions or periodic assessments if the participant misses more than two assessment sessions. Taking medications that interact with duloxetine during the study, such as MAO inhibitors or other antidepressants that are prohibited in the protocol. Initial misdiagnosis or failure to meet inclusion criteria after further review, such as diagnosis of a different type of cancer or a history of prior neuropathy that was not initially reported. Evidence of neuropathy or diseases that cause neuropathy by themselves prior to study entry Renal disorders that have occurred in the patient Not receiving chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropathy. Timepoint: each 2 or 3 weeks. Method of measurement: questionnaire and physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of neuropathy. Timepoint: each 2 or 3 weeks. Method of measurement: questionnaire and physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactmehrpouya mashhadizadeh
Artesh University of Medical Sciences
Outcome results
None listed