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Comparison of the Effect of Oral versus Sublingual Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Levels in Medical Students with Vitamin D Deficiency: A Randomized Clinical Trial

Comparison of serum levels of 25-hydrovitamin D after taking oral or sublingual vitamin D in medical students with insufficient serum vitamin D

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250904067125N1
Enrollment
60
Registered
2025-09-14
Start date
2025-10-21
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D deficiency. Vitamin D deficiency

Interventions

Intervention 1: Intervention Group 1: Patients in this group will receive one 50,000 IU vitamin D pearl (D-Vitin
manufactured by Zahravi Pharmaceutical Company) weekly for 8 weeks. Serum vitamin D levels will be remeasured at the end of the eighth week. Intervention 2: Intervention Group 2: Patients in this grou

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Being a medical student at Zahedan University of Medical Sciences. Aged between 18 and 30 years. Diagnosed with vitamin D deficiency, defined as a serum 25-hydroxyvitamin D level below 20 ng/mL. Willingness to participate and provision of signed informed consent. Not having taken any vitamin D or calcium supplements within the 3 months prior to the start of the study.

Exclusion criteria

Exclusion criteria: Presence of chronic diseases affecting vitamin D or calcium metabolism (e.g., renal or hepatic failure, hyperparathyroidism, sarcoidosis). Presence of malabsorption syndromes (e.g., celiac disease, Crohn's disease, ulcerative colitis). Use of medications known to interfere with vitamin D metabolism (e.g., anticonvulsants, systemic glucocorticoids, azole antifungals). History of hypercalcemia or calcium kidney stones. Pregnancy or lactation. Known hypersensitivity to vitamin D or any excipients in the study tablets. Unwillingness to continue cooperation or concurrent participation in another clinical trial.

Design outcomes

Primary

MeasureTime frame
Serum vitamin D level. Timepoint: Measurement of serum vitamin D levels at baseline and at the end of the eighth week. Method of measurement: Based on the measurement of serum 25-hydroxyvitamin D levels in the laboratory.

Secondary

MeasureTime frame
Serum vitamin D level. Timepoint: Measurement of serum vitamin D levels at baseline and at the end of the eighth week. Method of measurement: Based on the measurement of serum 25-hydroxyvitamin D levels in the laboratory.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahpari Zafar Zamen

Zahedan University of Medical Sciences

Dr.zafarzamen@zaums.ac.ir+98 54 3329 5770

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026