Administration of liver and kidney protective agent

The effect of intravenous administration of N-acetylcysteine during cardiopulmonary bypass on hepatic and renal function and cardiac enzymes in patients undergoing coronary artery bypass surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250901067077N1

Enrollment

Registered

2025-10-24

Start date

2025-10-18

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with coronary artery involvement.

Interventions

Intervention 1: Intervention group:Intervention group: Patients will be randomly divided into two groups receiving N-acetylcysteine ??and a control group. Patients in the receiving group will receive

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adult patients (over 18 years of age) undergoing first-time elective coronary artery bypass graft (CABG) surgery. Patients with a left ventricular ejection fraction (LVEF) of 30% or higher.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative cardiac enzyme levels are lower in the intervention group. Timepoint: Evaluation of patients’ liver function tests (LFTs) before and after surgery – assessment of reoperation due to bleeding – evaluation of inotropes used during surgery and within 24 hours after ICU admission. Method of measurement: The measurement of cardiac enzymes is performed using the corresponding laboratory test kits.	—

Measure

Time frame

Postoperative cardiac enzyme levels are lower in the intervention group. Timepoint: Evaluation of patients’ liver function tests (LFTs) before and after surgery – assessment of reoperation due to bleeding – evaluation of inotropes used during surgery and within 24 hours after ICU admission. Method of measurement: The measurement of cardiac enzymes is performed using the corresponding laboratory test kits.

—

Secondary

Measure	Time frame
Reduction in length of stay in the intensive care unit (ICU). Timepoint: The time points for measuring the length of hospital stay as a secondary outcome are 48 to 72 hours postoperatively. Method of measurement: The method of measurement is based on the corresponding checklist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Kheyabadi

Shahid Rajaei Cardiovascular, Medical, Research, and Training Institute

kheirabadia931@gmail.com+98 21 23921

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026