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Evaluation the effect of low-power 980 nm laser on intrapulpal injection pain

Evaluation the effect of low-power ??? nm laser on intra pulpal injection pain in mandibular first and second molars with symptomatic irreversible pulpitis: A randomized, double-blind clinical trial study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250831067058N1
Enrollment
56
Registered
2026-04-18
Start date
2026-05-31
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis. Irreversible pulpitis

Interventions

Intervention 1: Control group: Laser sham (placebo) + intrapulpal injection: In this group, the laser will be used in the off mode. Intervention 2: Intervention group: Low-power laser irradiation with

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients requiring root canal therapy have signs and symptoms of irreversible pulpitis in the mandibular first and second molars in whom a mandibular nerve block anesthetic injection has not been successful and who have pain during access cavity preparation. Requires intra pulpal injection Has systemic health Signing a written and informed consent form Cold testing using EndoFrost will be performed on the mandibular first and second molars and the contralateral tooth. Teeth that respond positively will be included in the study. Teeth with moderate, sharp, and spontaneous pain, a preoperative VAS score greater than 5, or pain stimulated by heat or cold that persisted after removal of the stimulus, without pain on biting or tapping, and without periapical changes or lesions (periapical index =2) will be included in the study.

Exclusion criteria

Exclusion criteria: Teeth with crown/root fractures, acute or chronic apical abscess, necrosis, damaged periodontium, or open apex Presence of physical disability, mental problems, or facial paresthesia (tingling or numbness) History of sensitivity to local anesthetic solutions Patients who have had a history of taking long-term medications that affect pain threshold, such as painkillers, steroids, or antibiotics, in the past 24 hours Teeth that are observed as non-vital during access cavity preparation

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before and during intra pulpal injection. Method of measurement: Based on the visual analog scale (VAS): Patients will indicate their pain level on a 10-centimeter line (VAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammad Hosein Nekoofar

Tehran University of Medical Sciences

nekoofar@yahoo.com+98 21 4279 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026