The effect of pulsatile perfusion on the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio around surgery in patients undergoing coronary artery bypass.. Ischemic heart diseases
Conditions
Interventions
Intervention 1: Intervention group: Pulsatile perfusion with 60-80 pulse/min, Base flow 30-40%, Pulse width 40-50% Parameters that will be initiated following cardioplegia administration and maintaine
Sponsors
Shahid Rajaee Heart and Vascular Educational, Research, and Treatment Institute
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Coronary Artery Bypass Graft candidate Aged 18 to 75 Ejection Fraction more than 40 percent
Exclusion criteria
Exclusion criteria: Lack of consent from eligible patients for study enrollment Complex or valvular surgery Type 1 Diabetes Aged more than 75 or lower than 18 Ejection Fraction lower than 40 percent Moderate or severe Carotid Stenosis Chronic alcohol usage Corticosteroid therapy and Radiotherapy Chronic Obstructive Pulmonary Disease Chronic renal failure History of brain stroke in the past six months Autoimmune disease Severe anemia Known coagulopathy Peripheral vascular disease History of systemic inflammatory disease Known allergic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Neutrophil to lymphocyte Ratio as inflammatory marker. Timepoint: Pre bypass, Upon Intensive Care Unit admission and 24 hours later. Method of measurement: Patient file.;Changes in Platelet to Lymphocyte Ratio as inflammatory marker. Timepoint: Pre bypass, Upon Intensive Care Unit admission and 24 hours later. Method of measurement: Patient file. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the arterial Lactate level. Timepoint: Pre intervention, Intra and post bypass, Upon Intensive Care Unit admission and 24 hours later. Method of measurement: Arterial blood sample.;Changes in plasma Hemoglobin level. Timepoint: Pre intervention, Intra and post bypass, Upon Intensive Care Unit admission and 24 hours later. Method of measurement: Arterial blood sample.;Changes in Mean Arterial Pressure. Timepoint: Pre intervention, Intra and post operation. Method of measurement: Intra Arterial Catheter.;Changes in Cerebral Oximetry. Timepoint: Pre intervention, Intra and post operation. Method of measurement: Near Infrared Spectroscopy machine.;Discoloration of urine. Timepoint: After catheterization, During aortic clamp and following bypass. Method of measurement: Visual assessment of urinary catheter bag. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSamaneh Alilou
Shaheed Rajaie Cardiovascular Medical and Research Institute
Outcome results
None listed