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Effect of corticosteroid and platelet-rich plasma (PRP) injections in unicameral bone cysts

Comparison of the effects of corticosteroids and PRP on proximal humerus UBC cysts

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250823066963N1
Enrollment
84
Registered
2025-09-01
Start date
2025-08-28
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unicameral bone cyst (UBC) of the proximal humerus. Solitary bone cyst

Interventions

Intervention 1: Intervention group: Intracystic combined injection of corticosteroid and platelet rich plasma (PRP). In this group, under sterile conditions and fluoroscopic guidance, 54 milliliters o

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 20 Years

Inclusion criteria

Inclusion criteria: Age under 20 years Initial diagnosis of unicameral bone cyst (UBC) in proximal humerus based on radiography

Exclusion criteria

Exclusion criteria: Lack of willingness of the patient or parents to participate in the study Inability to attend clinical or radiographic follow up Presence of hematologic diseases such as thalassemia, sickle cell anemia, or hemophilia Presence or history of malignancy Diabetes mellitus with poor glycemic control Presence of pathological fracture in the proximal humerus History of any previous treatment for unicameral bone cyst including injection or curettage Presence of hereditary or acquired immunodeficiency Known allergy to methylprednisolone acetate or related compounds

Design outcomes

Primary

MeasureTime frame
Radiographic healing of proximal humerus unicameral bone cyst based on ossification index and Neer classification. Timepoint: Baseline (before intervention), one month after injection, three months after injection. Method of measurement: Radiographic imaging in anteroposterior and lateral views and evaluation by ossification index and Neer classification performed by an orthopedic specialist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Torabi nejad kermani

Kerman University of Medical Sciences

Alitorabinejad99@gmail.com+98 34 3244 5959

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026