Type 2 Diabetes.
Conditions
Interventions
Intervention 1: First intervention group: Daily intake of 2000 units of vitamin D and one placebo magnesium tablet. Intervention 2: Second intervention group: Daily administration of 1 250 mg magnesiu
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Participants must be between 30 and 70 years old have a diagnosis of diabetes based on the criteria of the American Diabetes Association (HbA1C greater than 6.5 or FBS greater than 126 or OGTT greater than 200) confirmed by tests and an endocrinologist, be taking oral antidiabetic medications.
Exclusion criteria
Exclusion criteria: Use of insulin use of vitamin D supplements within three months before the start of the intervention, use of calcium supplements and magnesium supplements use of calcium and magnesium channel blocking drugs, use of diuretic drugs, use of drugs that interfere with vitamin D, including: corticosteroids, antiepileptic drugs and contraceptives patients with reduced kidney function (serum creatinine level more than 1.3 mg/dL in women and more than 1.5 mg/dL in men) increased liver enzymes (more than three times higher than normal values) kidney failure, chronic kidney disease ,Cushing's syndrome , kidney stones acute liver disease HIV and tuberculosis chronic obstructive pulmonary disease organ transplant bone disease autoimmune disease chronic inflammatory disease (inflammatory bowel disease, psoriasis, chronic asthma) hypercalcemia Cancers cardiovascular disease history of cerebrovascular disease or stroke in the past years severe anemia requiring blood transfusion uncontrolled blood pressure psychiatric disorder, dementia pregnancy or breastfeeding history of bariatric surgery use of tanning devices before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FBS. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;HbA1C. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;Serum vitamin D. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test. | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;LDL. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;TG. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;HDL. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;Cholesterol. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Blood test.;Weight. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: Scales.;BMI. Timepoint: Day 0 and 56 days after supplementation. Method of measurement: weight divided by the square of hight. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mostafa Nachvak
Kermanshah University of Medical Sciences
Outcome results
None listed