The effect of platelet rich fibrin on neurosensory recovery following sagittal split osteotomy

The effect of platelet rich fibrin on neurosensory recovery following sagittal split osteotomy, A double- blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250815066858N1

Enrollment

Registered

2025-08-30

Start date

2025-10-12

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurosensory recovery following sagittal split osteotomy.

Interventions

Intervention 1: Intervention group: Platelet-rich fibrin is used after osteotomy and before fixation on one side of the osteotomy (group 1 or intervention). Intervention 2: Control group: Platelet-ric

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: skeletal discrepancy Class II or III patients undergoing bilateral sagittal split osteotomy surgery

Exclusion criteria

Exclusion criteria: History of trauma to the mandible History of orthognathic surgery and genioplasty Obvious nerve damage during surgery, for example, complete or incomplete nerve transection History of medication use due to mental disorders

Design outcomes

Primary

Measure	Time frame
Evaluation of lower lip anesthesia following sagittal split osteotomy. Timepoint: It is done at intervals of one month, three months and six months. Method of measurement: To assess sensory nerve recovery, the brush stroke directional discrimination test using a brush and the 2-point discrimination using a gauge, the patient's self-report of numbness using a Visual Analogue Scale, and the patient's detection of temperature using ethyl chloride spray and cotton swabs are performed.	—

Measure

Time frame

Evaluation of lower lip anesthesia following sagittal split osteotomy. Timepoint: It is done at intervals of one month, three months and six months. Method of measurement: To assess sensory nerve recovery, the brush stroke directional discrimination test using a brush and the 2-point discrimination using a gauge, the patient's self-report of numbness using a Visual Analogue Scale, and the patient's detection of temperature using ethyl chloride spray and cotton swabs are performed.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbolfazl Razi Avarzamani

Tehran University of Medical Sciences

dr.abolfazlrazi@gmail.com+98 21 8490 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026