Apixaban alone or following Enoxaparin: Which Is more effective in preventing post-thrombotic syndrome in patients with deep vein thrombosis?

Comparison of the Preventive effects of two regimens "Enoxaparin followed by Apixaban" and "Apixaban alone" from Post Thrombotic Syndrome in patients with Deep Vein Thrombosis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250814066856N1

Enrollment

266

Registered

2025-09-15

Start date

2025-08-20

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Deep vein thrombosis. Condition 2: Postthrombotic syndrome. Acute embolism and thrombosis of unspecified deep veins of proximal lower extremity Postthrombotic syndrome

Interventions

Intervention 1: five-day course, enoxaparin will be discontinued, and treatment will immediately continue with oral apixaban at a dose of five milligrams every twelve hours. All medications are referr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients admitted to Imam Reza Hospital in Tabriz with a diagnosis of proximal deep vein thrombosis (DVT) of the lower extremities.

Exclusion criteria

Exclusion criteria: Lack of consent to participate in the study Patients with upper extremity deep vein thrombosis (DVT) Patients with distal deep vein thrombosis (DVT) of the lower extremity

Design outcomes

Primary

Measure	Time frame
Villalta Score for Post-thrombotic Syndrome (PTS). Timepoint: Six months after hospital discharge, post-thrombotic syndrome will be evaluated in patients. Method of measurement: Villalta Score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Riazi

Tabriz University of Medical Sciences

Nimariyazi@gmail.com+98 41 3337 3966

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026