Healthy Mountaineers.
Conditions
Interventions
Intervention 1: Intervention 1 : Acetazolamide + stimulation of M1 Before each exercise session, participants must take seven 125 mg capsules of acetazolamide. Administrati
Sponsors
Vice-Chancellor for Research, Razi University
Eligibility
Sex/Gender
Male
Age
18 Years to 44 Years
Inclusion criteria
Inclusion criteria: Men aged 18 to 44 years Active mountaineers (with a history of ascents to altitudes above 4,000 meters and regular mountaineering activities in the past year) Regular aerobic training at least three sessions per week (including mountaineering and hiking) History of acute mountain sickness (AMS) during previous overnight stays at altitudes above 3,000 meters Obtaining a medical certificate of fitness for participation in the exercise training program
Exclusion criteria
Exclusion criteria: Overnight stay at an altitude above 2,700 meters within two weeks prior to the start of the study Use of acetazolamide within two weeks prior to the start of the study Allergy to acetazolamide or sulfonamides Presence of any cardiovascular, pulmonary, or metabolic disease History of seizures, epilepsy, or other types of neurological disorders Presence of implanted medical devices or pacemakers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Continuous Performance Test (CPT). Timepoint: During exercise. Method of measurement: Computerized Continuous Performance Test (CPT).;EMG amplitude. Timepoint: During exercise. Method of measurement: 16-channel wireless electromyography (EMG) device (Noraxon, Scottsdale, AZ 85260, Germany.;Choice reaction time. Timepoint: After brain stimulation, after exercise. Method of measurement: Choice Reaction Time Apparatus, Model (Indiana, Lafayette, 63035A, Panel Respon).;Time to exhaustion. Timepoint: During exercise. Method of measurement: Running on a treadmill until reaching 90% of maximum heart rate or a rating of 19 on the Borg Rating of Perceived Exertion scale.;SpO2. Timepoint: During brain stimulation, During fatiguing exercise. Method of measurement: Pulse oximeter (Nonin, USA).;Stroop Color–Word. Timepoint: After brain stimulation, after exercise. Method of measurement: Computerized Stroop Test.;Borg Rating of Perceived Exertion. Timepoint: During fatiguing exercise. Method of measurement: Borg Rating of Perceived Exertion (RPE) scale, 6–20.;Sense of pleasure. Timepoint: During fatiguing exercise. Method of measurement: The Feeling Scale (FS; ranging from –5 to +5) was used, with responses recorded on a 5-point Likert-type scale.;Felt Arousal Scale. Timepoint: During fatiguing exercise. Method of measurement: The Felt Arousal Scale (FAS; ranging from +1 to +6) was used, and its mean scores were analyzed on a 6-point Likert-type scale.;Heart rate. Timepoint: During fatiguing exercise. Method of measurement: Polar heart rate monitor.;Y-Balance. Timepoint: After brain stimulation, after exercise. Method of measurement: The maximum reach of the stance and non-stance leg was measured in three specified directions: (1) anterior, (2) posteromedial, and (3) posterolateral. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRezvan Kheirandish
The Razi University of Kermanshah
Outcome results
None listed