stability of coated orthodontic mini-screws with zinc oxide nanoparticles , peri-miniscrew gingival condition and patient pain belief. -
Conditions
Interventions
Intervention 1: Intervention group 1 (Photodynamic therapy): Titanium miniscrew, 1.6 mm diameter and 10 mm length (American Orthodontics, Sheboygan, WI, USA), coated with zinc oxide nanoparticles (ZnO
Pishgaman Nanomavad Iranian, Mashhad, Iran) using electrostatic spray deposition. After placement, LED irradiation at 450±5 nm and 1000–1400 mW/cm² will be applied for 1 min, repeated once more after
Pishgaman Nanomavad Iranian, Mashhad, Iran) using electrostatic spray deposition. No LED irradiation will be applied in this group. Intervention 3: Intervention group 3 (LED): Titanium miniscrew, 1.6
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 28 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 28 who are periodontally healthy. Require the use of mini-screws for orthodontic treatment. The orthodontic treatment plan for these patients (diagnosed with Class II Division I malocclusion) involves extraction of the maxillary first premolars and requires absolute anchorage.
Exclusion criteria
Exclusion criteria: Active gag reflex, smoking, presence of periodontal disease, additional forces including mechanical forces from orthodontics and traumatic occlusion, systemic diseases that interfere with tissue healing such as diabetes, treatment with high-dose steroids, radiotherapy, or immunosuppressive therapies, pregnancy, breastfeeding, gastrointestinal problems, and allergy to impression materials. Patients who do not attend regular follow-up visits after mini-screw placement. History of medication use that interferes with healing or causes gingival overgrowth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stability. Timepoint: Immediately after placing the mini-screw and on days 7, 14, and 30 after placement. Method of measurement: Osstell ISQ RFA device. | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of inflammatory factors (TNF-a and IL-1ß). Timepoint: Immediately after mini-screw placement and on days 7, 14, and 30. Method of measurement: ELISA Kit.;Gingival index score. Timepoint: Immediately after placing the mini-screw and on days 7, 14, and 30 after placement. Method of measurement: Modified Gingival Index based on Löe & Silness.;Pain. Timepoint: Immediately after placing the mini-screw and on 7th after placement. Method of measurement: Visual Analogue Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRashin Bahrami
Iran University of Medical Sciences
Outcome results
None listed