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The effect of 5% dextrose injection on carpal tunnel syndrome

Clinical efficacy of ultrasound-guided prineural dextrose prolotherapy in mild-to-moderate carpal tunnel syndrome

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250810066808N1
Enrollment
70
Registered
2025-08-21
Start date
2025-08-23
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal tunnel syndrom. Carpal tunnel syndrome

Interventions

Intervention 1: Intervention group: Injection of 2 ml of Dextrose water 5% (Samen Pharmaceuticals, Iran) with a 25 gauge needle, in-plane method using a 13 MHz prop of the SONOSITE ultrasound device.

Sponsors

Kashan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 30-65 with mild to moderate carpal tunnel syndrome At least 3 months have passed since the onset of symptoms. Has not responded to conservative treatments including splinting, lifestyle modification, and energy preservation techniques Diagnosis of mild-to-moderate severity of carpal tunnel syndrome based on electrodiagnostic criteria

Exclusion criteria

Exclusion criteria: Previous history of polyneuropathy, symptomatic radiculopathy, brachial plexopathy, thoracic outlet syndrome History of wrist surgery or intralesional steroid injection within the past year Rheumatic diseases, fractures or deformities at the injection site Thenar atrophy and severe CTS Pregnancy, coagulopathy, and hypercoagulable conditions Neoplasm or skin infection at the injection site, sensitivity to corticosteroids

Design outcomes

Primary

MeasureTime frame
Boston Questionnaire-Symptom Severity scores in the two groups treated with perineural steroid injection and prolotherapy. Timepoint: At the beginning of the study and then 1 and 4 months after the intervention. Method of measurement: Boston Questionnaire-Symptom Severity Questionnaire.;Boston Questionnaire-Functional status scores in the two groups treated with perineural steroid injection and prolotherapy. Timepoint: At the beginning of the study and then 1 and 4 months after the intervention. Method of measurement: Boston Questionnaire- Functional status Questionnaire.

Secondary

MeasureTime frame
Average pain intensity using the Visual Analog Scale in the two groups treated with perineural steroid injection and prolotherapy. Timepoint: At the beginning of the study and then 1 and 4 months after the intervention. Method of measurement: Visual Analog Scale Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSareh Sokout Arani

Kashan University of Medical Sciences

sokout-s@mail.kaums.ac.ir+98 31 5474 0021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026