Investigating the effect of oral administration of Bromelain on the dental socket epithelialization rate after premolar extraction.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250809066793N1

Enrollment

Registered

2025-10-23

Start date

2025-11-11

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Investigating the effect of oral administration of Bromelain on the dental socket epithelialization rate after premolar extraction..

Interventions

Intervention 1: Control Group: (No medication)Intervention timeline:Once immediately after surgery, and two more times after three days and seven days.Following the extraction of the premolar tooth, t

Eligibility

Sex/Gender

All

Age

15 Years to 35 Years

Inclusion criteria

Inclusion criteria: Age over 15 years and under 35 years, willingness to participate in the study, systemic health, requirement for the extraction of two premolar teeth

Exclusion criteria

Exclusion criteria: evelopment of a new systemic disease during the study unwillingness to continue participation in the study requirement for surgical extraction of the tooth

Design outcomes

Primary

Measure	Time frame
Buccolingual dimensions of the crest:The distance from the buccal crest to the lingual crest of the extraction socket. Timepoint: 7 day. Method of measurement: Examination with a UNC 15 probe.;Mesiodistal dimensions of the crest.: The distance from the mesial crest to the distal crest of the extraction socket. Timepoint: 2 days. Method of measurement: Examination with a UNC 15 probe.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Saina Nezaminia

Karaj University of Medical Sciences

sayna.nezaminia@gmail.com+98 26 3419 7000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026