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Studying the effect of dexmedetomidine on acute kidney injury after traumatic shock

Studying the effect of dexmedetomidine on acute kidney injury after traumatic shock

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250809066790N1
Enrollment
60
Registered
2025-10-17
Start date
2025-11-21
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute kidney injury. Injury of kidney

Interventions

Intervention 1: Intervention group: Patients in the intervention group, after intubation and transfer to the ICU, are sedated with a continuous intravenous infusion of 0.5 µg/kg/hour (0.5 micrograms/k

Sponsors

Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-60 years with traumatic shock and undergoing mechanical ventilation who were admitted to the ICU after stabilization.

Exclusion criteria

Exclusion criteria: Patient death within the first 48 hours of ICU admission Lack of consent from patient companions to participate in the study Occurrence of acute kidney injury (AKI) or need for hemodialysis within the first 48 hours of hospitalization Extubation under 48 hours History of kidney disease who have previously undergone dialysis

Design outcomes

Primary

MeasureTime frame
Incidence of acute kidney injury (AKI) within the first 7 days of intensive care unit (ICU) admission. Timepoint: From the moment of admission to the ICU until the seventh day of hospitalization. Method of measurement: Based on an increase in serum creatinine = 0.3 mg/dL in 48 hours or = 1.5 times baseline within 7 days, or a decrease in urine output to < 0.5 mL/kg/hour for at least 6 hours.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Ramezani

Qazvin University of Medical Sciences

dr.rreza.60@gmail.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026