Mild knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: In this study, there are two intervention groups and no control group. The first intervention group receives PRP treatment, which is prepared from the patients’ own
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: ?Age between 35 and 75 years ?Outpatient visit to the Madani Hospital clinic with a complaint of knee pain ?At least 3 months having passed since the onset of symptoms such as knee pain ?Diagnosis of mild knee osteoarthritis by a specialist physician ?Knee pain intensity between 3 and 6 based on the Visual Analog Scale (VAS) ?Ability to walk independently and perform daily activities ?Signing of the informed consent from
Exclusion criteria
Exclusion criteria: Moderate or severe osteoarthritis Age under 35 or over 75 years Previous history of intra-articular injection Active infection or wound in the knee Platelet disorders History of knee surgery or knee trauma within the past 6 months History of other knee diseases such as avascular necrosis (AVN) or fractures Chronic use of anticoagulant or antiplatelet drugs, or their use within 10 days prior to injection Use of NSAIDs within 2 days prior to injection Systemic corticosteroid use within 2 weeks prior to injection Pregnancy or breastfeeding Body Mass Index (BMI) greater than 30 Hemoglobin less than 12 mg/dL or platelet count less than 150,000/µL Genu valgum or genu varum greater than 20 degrees History of allergy to egg protein, chicken feathers, or hypersensitivity to hyaluronates Treatment with ACE inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient pain based on the Visual Analog Scale (VAS); patient physical function based on the Knee Injury and Osteoarthritis Outcome Score (KOOS); patient quality of life based on the SF-36 questionnaire.Each will be compared between pre- and post-intervention. Timepoint: At the beginning of the study (before the intervention) and three months afterward. Method of measurement: Patient pain based on the Visual Analog Scale (VAS); patient physical function based on the Knee Injury and Osteoarthritis Outcome Score (KOOS); patient quality of life based on the SF-36 questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNarges Khalaji
Karaj University of Medical Sciences
Outcome results
None listed