Chronic kidney disease. Chronic kidney disease (CKD)
Conditions
Interventions
Intervention 1: Intervention group : Investigating the effect of sacubitril valsartan on echocardiographic characteristics and renal function indices in patients with chronic renal failure. Interventi
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with chronic renal failure over 18 years of age (uACR = 30 mg/g, GFR < 60 ml/min/1.73m2) 2. Patients with no contraindications or known tolerance to ARB 3. Patients without bilateral renal artery stenosis 4. Patients without nephrotic syndrome (350 mg/g) < urine protein: creatinine ratio or 300 mg/mmol < uACR or (Alb < 35 g/l) 5. Patients not taking immunosuppressive drugs 6. Patients not taking heparin or enoxaparin 7. Women other than pregnant, lactating women and all women who plan to become pregnant in the next 6 months 8. In case of alcohol consumption, a maximum of 2 ounces per day for men and 1 ounce per day for women and people without drug use 9. People without active malignancy 10. Patients who are able to stop their previous antihypertensive drugs
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Age, gender, systolic blood pressure, albuminuria, history of diabetes, plasma and urinary electrolytes, lipid profile, plasma albumin hs, CRP, Ejection Fraction, BMI, GFR, smoking status, diastolic blood pressure, pulmonary artery pressure, mitral regurgitation. Timepoint: At the beginning of the study, the first month, the third month, and the sixth month. Method of measurement: Laboratory sampling. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Amoutaghi
Kashan University of Medical Sciences
Outcome results
None listed