traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: they will receive standard care for treatment during the hospitalization period, as well as atorvastatin 10 mg orally or via NG tube from the first day of hospitali
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of traumatic brain injury (TBI) of mild to severe severity (based on GCS). ICU admission for at least 72 hours (to ensure adequate monitoring). No use of atorvastatin in the 3 months prior to hospitalization. No history of liver disease or elevated liver enzymes (ALT/AST > 3 times normal).
Exclusion criteria
Exclusion criteria: Concomitant use of drugs that interact with atorvastatin (such as some antibiotics, antifungals). Patients with GCS = 3 History of allergy to atorvastatin or any statin. History of statin-induced myopathy or rhabdomyolysis. TBI caused by suicide or non-accidental injuries (for moral and psychological reasons). Need for emergency surgery other than craniotomy (e.g., abdominal or thoracic surgery). Receiving strong anti-inflammatory medications (such as high-dose corticosteroids) within 7 days prior to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fibrinogen level. Timepoint: At the beginning of the study and 14 days later. Method of measurement: Blood test.;White blood cell count. Timepoint: At the beginning of the study and 14 days later. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmin Soleimani Mohammadi
Kerman University of Medical Sciences
Outcome results
None listed