Comparison of nebulized Salbutamol and nebulized salbutamol with ipratropium bromide in treatment of bronchiolitis symptoms in children under 2 years old

Comparison of the effect of salbutamol nebulizer versus salbutamol nebulizer combined with ipratropium bromide on the relief of bronchiolitis symptoms in children under 2 years of age

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250730066693N1

Enrollment

Registered

2025-11-09

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric pulmonary diseases. Acute bronchiolitis

Interventions

Intervention 1: Control group: The group receiving standard supportive treatment plus nebulized salbutamol every 3 hours on the first day and every 6 hours on the following days at a dose of 0.15 mg/k

Eligibility

Sex/Gender

All

Age

28 Days to 2 Years

Inclusion criteria

Inclusion criteria: Children between 28 days and 2 years Diagnosed with acute bronchiolitis by a pediatrician

Exclusion criteria

Exclusion criteria: Congenital heart disease Immunodeficiency Bronchopulmonary dysplasia Neuromuscular disease History of sensitivity to drugs used in intervention Asthma history in the child Requires ventilator Requires hospitalization in ICU Withdrawal of the patients parents from continuing to participate in the study The incidence of allergies to the drugs used in intervention

Design outcomes

Primary

Measure	Time frame
Duration of hospitalization. Timepoint: Number of days of hospitalization. Method of measurement: Number of days of hospitalization based on information recorded in the patient's file.;Body temperature. Timepoint: Before the start of the intervention and every day during hospitalization. Method of measurement: Mercury thermometer.;Bronchiolitis severity based on the "Children's Respiratory Severity Score" scoring table. Timepoint: Before the start of the intervention and every day during hospitalization. Method of measurement: Scoring is based on the provided table guide, which shows a score of 0-1 for mild, a score of 2-3 for moderate, and a score of 4-5 for severe disease.	—

Measure

Time frame

Duration of hospitalization. Timepoint: Number of days of hospitalization. Method of measurement: Number of days of hospitalization based on information recorded in the patient's file.;Body temperature. Timepoint: Before the start of the intervention and every day during hospitalization. Method of measurement: Mercury thermometer.;Bronchiolitis severity based on the "Children's Respiratory Severity Score" scoring table. Timepoint: Before the start of the intervention and every day during hospitalization. Method of measurement: Scoring is based on the provided table guide, which shows a score of 0-1 for mild, a score of 2-3 for moderate, and a score of 4-5 for severe disease.

—

Secondary

Measure	Time frame
Heart rate. Timepoint: Before the start of the intervention and every day during hospitalization. Method of measurement: Counting the patient's heart rate in one minute based on palpation of the radial artery.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Mohammadi

Shahre-kord University of Medical Sciences

fa.mo6301@gmail.com+98 31 3680 8960

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026