Delirium Superimposed on Dementia. Delirium due to known physiological condition
Conditions
Interventions
Intervention 1: Intervention group: Edaravone, IV infusion, 60mg in 200cc of normal saline, daily infusion for 5 days. Intervention 2: Control group: Delirious patients according to entry criteria, 20
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: acute delirious state a prior history of dementia or current diagnosis of dementia age>65 the patient's cooperation and the patient's or the caregiver's consent
Exclusion criteria
Exclusion criteria: the presence of other cognition-altering diseases or syndromes: depression, Parkinson, Huntington, normal pressure hydrocephalus, seizure, a prior history of moderate to severe head traumas, acute cerebral infarction, chronic psychiatric conditions auditory, visual or articulatory problems causing a misunderstanding of communication an underlying malignancy and life expectancy less than 6 months renal failure or creatinine clearance rate less than 5 liver failure and liver enzyme levels more than 2 times the normal range a positive screening test for HIV or hepatitis B or C chronic cardiovascular or respiratory disease an active infection prior use of cimetidine, diclofenac or probenecid substance or alcohol abuse in the prior 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Confusion Assessment Method Score. Timepoint: Before the treatment, 5 days after the treatment, 30 days after the treatment. Method of measurement: Confusion Assessment Method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium Rating Scale Score. Timepoint: Before the treatment, 5 days after the treatment, 30 days after the treatment. Method of measurement: Delirium Rating Scale.;Mini Mental State Examination Score. Timepoint: Before the treatment, 5 days after the treatment, 30 days after the treatment. Method of measurement: Mini Mental State Examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNika Keshtkaran
Tehran University of Medical Sciences
Outcome results
None listed