Prolonged Indirect Hyperbilirubinemia in Term Neonates. Neonatal jaundice, unspecified
Conditions
Interventions
Intervention 1: Intervention group: in this group , term neonates with prolonged Unconjugated Hyperbilirubinemia , recieves oral clofibrate at a dose of 50 mg/kg as a single dose. In addition , photot
Sponsors
Ilam University of Medical Sciences
Eligibility
Sex/Gender
All
Age
14 Days to 28 Days
Inclusion criteria
Inclusion criteria: The neonate is full-term with gestational age between 37 and 42 weeks Jaundice persists beyond the 14th day of birth The neonate has no underlying pathological conditions such as Infection , Liver disorders , Hypothyroidism , Cholestasis , Hemolysis , G6PD deficiency , Blood group incompatibilities , metabolic disorders The neonate has normal birth weight Written informed consent is obtained from the parents
Exclusion criteria
Exclusion criteria: The neonate has an active infection The neonate has liver disease , cholestasis or metabolic disorders The neonate has blood group incompatibility or G6PD deficiency The neonate has hypothyroidism The neonate is preterm (less than 37 weeks of gestation) The neonate has low birth weight ( Less than 2500 grams) Parents refuse to participate in the study Serum bilirubin level is high enough to require exchange transfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total serum bilirubin level in term neonates with prolonged indirect hyperbilirubinemia. Timepoint: Before the Intervention on day 1 , and on days 3 , 5 and 7 after the intervention. Method of measurement: At the beginning of the study, bilirubin levels will be measured using serum (blood) samples. In subsequent follow-ups, transcutaneous bilirubin will be used for monitoring to reduce invasiveness. However, if transcutaneous bilirubin levels are elevated or approach therapeutic thresholds, or if there is clinical discrepancy, serum measurements will be repeated to ensure data accuracy. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmadreza Heidarynezhad
Ilam University of Medical Sciences
Outcome results
None listed