Condition 1: Breast Cancer. Condition 2: Depressive episode. Condition 3: Sleep disorders. Condition 4: Generalized Anxiety Disorder. Malignant neoplasm of breast Mood disorder due to known physiological condition with major depressive-like episode Sleep disorders Generalized anxiety disorder
Conditions
Interventions
Intervention 1: The intervention group will receive intravenous dexmedetomidine. After induction of anesthesia, dexmedetomidine will be administered at a dose of 1 microgram per kilogram, followed by
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Mild to severe anxiety or depression symptoms Without systemic disease, or with controlled systemic disease
Exclusion criteria
Exclusion criteria: Patients with incomplete clinical data severe cardiac disease increased intracranial pressure epilepsy incomplete clinical data failure to complete the one-week follow-up allergy to intravenous anesthetic agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in NRS scores, opioid use, and adverse events (including cardiac complications, nausea, and dizziness). Timepoint: During the first 24 hours after surgery. Method of measurement: Numerical Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Depressive symptoms. Timepoint: on postoperative days 1, 3, and 7. Method of measurement: Patient Health Questionnaire–9 (PHQ-9).;Postoperative sleep quality improvement based on PSQI score. Timepoint: on postoperative days 1, 3, and 7. Method of measurement: The Pittsburgh Sleep Quality Index (PSQI) questionnaire.;Anxiety symptoms. Timepoint: on postoperative days 1, 3, and 7. Method of measurement: The 7-item Generalized Anxiety Disorder (GAD-7). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMalihe Abniki
Shahid Beheshti University of Medical Sciences
Outcome results
None listed