Comparison of the Effects of Propofol and Nesdonal on Reducing Cerebral Ischemia During Neurosurgical Procedures: A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250722066589N2

Enrollment

100

Registered

2025-08-03

Start date

2025-08-23

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparison of the Effects of Propofol and Nesdonal on Reducing Cerebral Ischemia During Neurosurgical Procedures.

Interventions

Intervention 1: Intervention group: propofol 2mg/kg. Intervention 2: Control group: nesdonal 5mg/kg.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Adult patients under brain surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Thirty minutes before the start of surgery , Two hours after the start of surgery, End of surgery. Method of measurement: Automatic blood pressure monitor.;Diastolic blood pressure. Timepoint: Thirty minutes before the start of surgery , Two hours after the start of surgery, End of surgery. Method of measurement: Automatic blood pressure monitor.;Heart rate. Timepoint: Thirty minutes before the start of surgery , Two hours after the start of surgery, End of surgery. Method of measurement: Patient monitoring system.;TNF-a. Timepoint: Before surgury , After surgery. Method of measurement: Blood serum.;IL-6. Timepoint: Before surgury , After surgery. Method of measurement: Blood serum.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Thirty minutes before the start of surgery , Two hours after the start of surgery, End of surgery. Method of measurement: Automatic blood pressure monitor.;Diastolic blood pressure. Timepoint: Thirty minutes before the start of surgery , Two hours after the start of surgery, End of surgery. Method of measurement: Automatic blood pressure monitor.;Heart rate. Timepoint: Thirty minutes before the start of surgery , Two hours after the start of surgery, End of surgery. Method of measurement: Patient monitoring system.;TNF-a. Timepoint: Before surgury , After surgery. Method of measurement: Blood serum.;IL-6. Timepoint: Before surgury , After surgery. Method of measurement: Blood serum.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMalihe Abniki

Shahid Beheshti University of Medical Sciences

dr.abniki@sbmu.ac.ir+98 21 25719

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026