Acute Kidney Injury. Acute kidney failure, unspecified
Conditions
Interventions
Intervention 1: Intervention Group: Participants will receive standard-of-care medical management for AKI plus a daily dose of 2 grams of Ajwain powder. The Ajwain will be administered orally as 500 m
Sponsors
Zabol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The study population will consist of adult patients, aged 18 to 65 years, admitted to participating hospitals in Zabol, Iran, with a confirmed diagnosis of Acute Kidney Injury (AKI) AKI will be defined and diagnosed according to the Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guidelines, as meeting any one of the following criteria :An absolute increase in serum creatinine (sCr) of =0.3 mg/dL (=26.5 µmol/L) within 48 hours A relative increase in sCr to =1.5 times the known or presumed baseline value, which is assumed to have occurred within the prior 7 days A documented reduction in urine output to <0.5 mL/kg/hour for a duration of at least 6 consecutive hours.
Exclusion criteria
Exclusion criteria: Pregnancy or current lactation Active malignancy or a history of any malignancy within the past 5 years Severe systemic infection or sepsis at the time of screening Significant hepatic impairment, defined as serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) levels greater than three times the upper limit of the normal reference range Known history of autoimmune disease Current or imminent requirement for renal replacement therapy (RRT) at the time of enrollment, or a history of RRT within the current hospital admission Pre-existing chronic kidney disease (CKD), defined as a known baseline estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m². Known hypersensitivity or allergy to Ajwain (Trachyspermum ammi) or any of its constituents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Creatinine. Timepoint: Every 72 hours. Method of measurement: Blood Test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAref Shahreki
Zabol University of Medical Sciences
Outcome results
None listed