effectiveness of two types of silver nanocrystal dressings (Agcoat) and silver sulfadiazine ointment with amniotic membrane

A comparative study of the effectiveness of two types of silver nanocrystal dressings (Agcoat) and silver sulfadiazine ointment with amniotic membrane in second- and third-degree burn wounds

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250719066557N1

Enrollment

Registered

2025-08-21

Start date

2026-01-05

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Second-degree burn. Condition 2: Third-degree burn. Burn of second degree, body region unspecified Burn of third degree, body region unspecified

Interventions

Intervention 1: Control group: Silver nanocrystal dressing (Agcoat) is used as a fabric-like product containing silver, which is considered a type of antibiotic in burn treatment, along with distilled

Eligibility

Sex/Gender

All

Age

2 Months to No maximum

Inclusion criteria

Inclusion criteria: Second and third degree burn wounds

Exclusion criteria

Exclusion criteria: Under two months old Pregnancy Breast feeding Favism disease Diabet Immune deficiency Collagen vascular disease Peripheral artery disease Immunosuppressive drug and corticosteroid Chronic kidney disease Electrical burn Chemical burn

Design outcomes

Primary

Measure	Time frame
The time required for wound healing or to prepare for skin grafting. Timepoint: One turn at the end of the study. Method of measurement: Calculation of the number of days of hospitalization and treatment.	—

Secondary

Measure	Time frame
Pain intensity. Timepoint: Pain intensity: before treatment, first day after treatment, 5 days after treatment, 10 days after treatment, 15 days after treatment, 20 days after treatment, end of treatment. Method of measurement: Pain intensity by calculating the VAS system score.;Infection rate. Timepoint: Culture from the wound bed on the first and fifth days. Method of measurement: Wound bed culture results on the first and fifth days.;Number of dressings. Timepoint: At the end of the study. Method of measurement: Number of dressings during the treatment period.;Severity of pain during dressing changes. Timepoint: Each time the dressing is applied. Method of measurement: By calculating the VAS system criteria.;The need for narcotics. Timepoint: At the end of the study. Method of measurement: By recording the dose of narcotic medication taken during the treatment period.;Cost of treatment system. Timepoint: At the end of the study. Method of measurement: By calculating the amount.	—

Measure

Time frame

Pain intensity. Timepoint: Pain intensity: before treatment, first day after treatment, 5 days after treatment, 10 days after treatment, 15 days after treatment, 20 days after treatment, end of treatment. Method of measurement: Pain intensity by calculating the VAS system score.;Infection rate. Timepoint: Culture from the wound bed on the first and fifth days. Method of measurement: Wound bed culture results on the first and fifth days.;Number of dressings. Timepoint: At the end of the study. Method of measurement: Number of dressings during the treatment period.;Severity of pain during dressing changes. Timepoint: Each time the dressing is applied. Method of measurement: By calculating the VAS system criteria.;The need for narcotics. Timepoint: At the end of the study. Method of measurement: By recording the dose of narcotic medication taken during the treatment period.;Cost of treatment system. Timepoint: At the end of the study. Method of measurement: By calculating the amount.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Moradianfard

Ahvaz University of Medical Sciences

Dr_hmf107040@yahoo.com0613550256

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026