Investigation of the effects of a combination of lemon balm leaf and full extract of lettuce seed on dental anxiety in patients.

Investigation of the Effects of a Combination of Lemon Balm Leaf and Full Extract of Lettuce Seed on Dental Anxiety in Patients Referred to the General Surgery Department of Isfahan Dental School in the Academic Year 2024-2025; A Double-Blind Randomized Clinical Trial.

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250719066550N1

Enrollment

Registered

2025-08-14

Start date

2025-07-18

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxious patients.

Interventions

Intervention 1: Intervention group: 100 mg capsule containing a combination of full extract of lettuce seed and lemon balm. Intervention 2: Control group: 100 mg capsule containing corn starch.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Sound mental health and ability to complete the questionnaire Ability to complete the questionnaire

Exclusion criteria

Exclusion criteria: History of allergy

Design outcomes

Primary

Measure	Time frame
There was no significant difference in anxiety levels between the intervention and control groups. Timepoint: Beginning of the study and after the intervention. Method of measurement: Questionnaire, heart rate, and oxygen saturation.;Heart beats. Timepoint: Before and after the intervention. Method of measurement: Pulse oximeter.;Oxygen saturation. Timepoint: Before and after the intervention. Method of measurement: Pulse oximeter.	—

Measure

Time frame

There was no significant difference in anxiety levels between the intervention and control groups. Timepoint: Beginning of the study and after the intervention. Method of measurement: Questionnaire, heart rate, and oxygen saturation.;Heart beats. Timepoint: Before and after the intervention. Method of measurement: Pulse oximeter.;Oxygen saturation. Timepoint: Before and after the intervention. Method of measurement: Pulse oximeter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSobhan Malekzadeh

Esfahan University of Medical Sciences

Sobhan.malekzadeh1@gmail.com+98 84 3223 3106

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026