Malignant neoplasm of myometrium. Malignant neoplasm of myometrium
Conditions
Interventions
Intervention 1: Intervention group: The intervention group receives 400 micrograms of misoprostol rectally 1 hour before the first abdominal myomectomy incision. Misoprostol is administered once befor
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women aged 18 to 45 years Patients with symptomatic intramural uterine fibroids- Presence of 1 to 3 uterine fibroids Uterine size equivalent to 14–16 weeks of gestation Patients who provide informed consent to participate in the study Uterine fibroids larger than 5 cm in diameter Preoperative hemoglobin level above 10 g/dL
Exclusion criteria
Exclusion criteria: Patients with known bleeding disorders (e.g., hemophilia, von Willebrand disease) Patients currently receiving anticoagulant therapy or other medications affecting coagulation Breastfeeding women Patients with hepatic disease, cardiomyopathies, congestive heart failure (CHF), ischemic heart disease (IHD), hypertension (HTN), dyslipidemia, diabetes, or recent vascular thrombosis Patients with gynecological malignancies Prior treatment with gonadotropin-releasing hormone (GnRH) analogues Preoperative hemoglobin level below 10 g/dL Patients with a history of allergic reactions to misoprostol or other contraindications to its use - Patients with a body mass index (BMI) above 35 kg/m², as it may complicate surgery and affect outcomes Patients with multiple large fibroids that may significantly alter the standard abdominal myomectomy procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss (mL). Timepoint: Intraoperative blood loss (mL) assessed during surgery. Method of measurement: Intraoperative blood loss (mL):Measured by summing:Volume in suction container (mL).Weight of soaked surgical gauzes (1g = 1mL blood). | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin levels (mg/dL). Timepoint: Measured via standard lab tests (pre-op and 24h post-op). Method of measurement: standard lab tests.;Surgery duration (minutes). Timepoint: ecorded from first incision to closure. Method of measurement: Recorded from first incision to closure (OR timer).;Need for blood transfusion (yes/no). Timepoint: Documented if hemoglobin drops below 7 mg/dL (hospital protocol). Method of measurement: Documented if hemoglobin drops below 7 mg/dL (hospital protocol). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFaezeh Hosseini
Qazvin University of Medical Sciences
Outcome results
None listed