Parkinson. Parkinson's disease
Conditions
Interventions
Intervention group: Control Group: No intervention
patients continue usual activities and standard medications (e.g., levodopa).Intervention Group 1: Aerobic exercise
4 weeks, 3 sessions/week, 20-minute treadmill walking at 60-80% max heart rate, with 5-minute warm-up and cool-down, monitored by physician and Polar device.Intervention Group 2: Aerobic exercise (as
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients should be in stages 2 and 3 of the disease, have a stable medication regimen for at least 2 months before the study, and be in generally good health. They should have no issues with walking or balance that would prevent them from performing the exercise protocol. Additionally, participants must have a stable medication regimen for at least 2 months before starting the exercise. They should be aged 30 to 80 years, have no orthopedic, cardiac, or blood pressure issues, be non-tobacco users, and refrain from using specific supplements in the 2 months preceding the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Variables:Serum concentration of IL-1ßSerum concentration of IL-6Serum concentration of IL-10Serum concentration of TNF-aClinical status of Parkinson’s disease patients (assessed using the UPDRS questionnaire). Timepoint: Baseline: 48 hours before intervention (blood sampling: 8-9 AM after 12-hour fasting; UPDRS: study start).Post-Intervention: 48 hours after 4-week intervention (blood sampling: 8-9 AM after 12-hour fasting; UPDRS: study end). Method of measurement: Cytokines (IL-1ß, IL-6, IL-10, TNF-a): ELISA method, 5 mL venous blood, after 12-hour fasting, 8-9 AM.Clinical Status: UPDRS questionnaire, at study start and end. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Akbar Karimi
Islamic Azad University
Outcome results
None listed