The effect of gonadotropin-releasing hormone agonist (GnRH agonist) in embryo transfer cycles

Study and comparison of the effect of single-dose and double-dose injection of gonadotropin-releasing hormone agonist (GnRH Agonist) for luteal phase support in frozen embryo transfer cycles

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250714066484N1

Enrollment

300

Registered

2026-05-19

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility undergoing frozen embryo transfer. Female infertility

Interventions

Intervention 1: Intervention group: Control group: Participants will receive standard hormone therapy for luteal phase support, including vaginal progesterone suppositories and intramuscular progester

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women who have frozen embryos and are candidates for frozen embryo transfer Age less than 40 years

Exclusion criteria

Exclusion criteria: Women over 40 FSH greater than or equal to 20 Women who have an endometrial thickness of less than 7 before embryo transfer Women with uterine abnormalities Women with intramural myomas larger than 4 cm and subserosal fibroids Chromosomal abnormalities in men and women - poor embryo quality

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate after frozen embryo transfer. Timepoint: Serum beta-hCG will be measured 14 days after embryo transfer. In cases with appropriate rise in beta-hCG, transvaginal ultrasound will be performed approximately 2 weeks later to assess clinical pregnancy. Method of measurement: Clinical pregnancy will be assessed by transvaginal ultrasound and defined as the presence of an intrauterine gestational sac after a positive serum beta-hCG test.	—

Measure

Time frame

Clinical pregnancy rate after frozen embryo transfer. Timepoint: Serum beta-hCG will be measured 14 days after embryo transfer. In cases with appropriate rise in beta-hCG, transvaginal ultrasound will be performed approximately 2 weeks later to assess clinical pregnancy. Method of measurement: Clinical pregnancy will be assessed by transvaginal ultrasound and defined as the presence of an intrauterine gestational sac after a positive serum beta-hCG test.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactfereshte faramarzi

Tehran University of Medical Sciences

faramarzi.fereshte@gmail.com+98 21 8490 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026