The Effect of Mindfulness-Based Stress Reduction (MBSR) on Anxiety Sensitivity, Perceived Stress, Emotion Dysregulation, and Blood Oxidative and Antioxidative Markers

The Effectiveness of Mindfulness-Based Stress Reduction Therapy on Perceived Stress, Anxiety Sensitivity, Emotion Regulation Difficulties, and Oxidative Stress Factors (Oxidant/Antioxidant) in Patients with Chronic Obstructive Pulmonary Disease (COPD)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250713066470N1

Enrollment

Registered

2025-07-21

Start date

2025-09-06

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease, unspecified

Interventions

Intervention 1: Intervention group: 8-week mindfulness-based stress reduction (MBSR). Intervention 2: Control group: The control group does not receive any intervention or treatment.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Having chronic obstructive pulmonary disease based on the diagnosis of the lung specialist Participants aged between 18 to 60 years Having a written informed consent to participate in the study Participants must have no diagnosis of major depressive disorder or any anxiety disorders Participants must have no prior history of receiving psychological interventions ( especially mindfulness-based interventions) by a psychologist or psychiatrist Participants must have no prior diagnosis of arthritis in the medical history Participants must have no history of metabolic disorders, including diabetes or hypertension in their medical history Participants must not use vitamin D,C,E supplements or any other dietary suuplements that influence plasma oxidative and antioxidant factor levels

Exclusion criteria

Exclusion criteria: Participants with absence from more than two treatment sessions Participants who incompletely compllete the questionnaris Use of psychiatric medications Any changes in medication use or treatment during the study Participants will be excluded if they develop an acute or emergency medical condition during the implement of the study

Design outcomes

Primary

Measure	Time frame
THE perceived stress score in the Cohen perceived stress scale. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: Cohen perceived stress scale.;The anxiety sesitivity score in the Floyd anxiety sensitivity scale. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: Floyd anxiety sensitivity inventory.;The emotion dysregulation score in the 16-item Difficulties in Emotion Regulation Scale. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: The 16-item Difficulties in Emotion Regulation Scale (DERS-16) by Bjureberg.;Levels of oxidative and antioxidant blood factors (MDA, TOS, TAC, Thiol groups) measured using diagnostic assy kits. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: Assy kits for TAC, MDA, TOS, Thiol groups.	—

Measure

Time frame

THE perceived stress score in the Cohen perceived stress scale. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: Cohen perceived stress scale.;The anxiety sesitivity score in the Floyd anxiety sensitivity scale. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: Floyd anxiety sensitivity inventory.;The emotion dysregulation score in the 16-item Difficulties in Emotion Regulation Scale. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: The 16-item Difficulties in Emotion Regulation Scale (DERS-16) by Bjureberg.;Levels of oxidative and antioxidant blood factors (MDA, TOS, TAC, Thiol groups) measured using diagnostic assy kits. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (after the intervention). Method of measurement: Assy kits for TAC, MDA, TOS, Thiol groups.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Habibi

Kashan University of Medical Sciences

habibisara422@gmail.com+98 71 3736 9497

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026