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The comparison of the effectiveness of online group therapy and in-person therapy on depression and anxiety in patients with MS (Multiple Sclerosis).

Effectiveness of Online vs. In-Person Unified Protocol Group Therapy on Transdiagnostic Components in Patients with Multiple Sclerosis Comorbid with Depression and Anxiety

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250708066412N1
Enrollment
40
Registered
2025-11-01
Start date
2025-07-30
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple Sclerosis

Interventions

Intervention 1: Intervention group: In-Person Transdiagnostic Cognitive-Behavioral Therapy (Unified Protocol)** The intervention will be delivered in person using the Transdiagnostic Cognitive-Behavi

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Diagnosis of Multiple Sclerosis Minimum literacy level (at least middle school education) No history of addiction No other psychological treatments received during the study Age between 20 and 40 years No acute psychiatric disorders No severe physical disability, such as dependence on a wheelchair Score between 0 and 16 on the BDI-II (Beck Depression Inventory-II) Score between 0 and 25 on the BAI (Beck Anxiety Inventory)

Exclusion criteria

Exclusion criteria: Development of severe psychiatric disorders Relapse of the disease or severe physical disability Development of severe physical disability (such as wheelchair dependence) during the study Absence from more than two sessions Recent experience of an acute psychological crisis Score higher than 16 on the BDI-II Score higher than 25 on the BAI

Design outcomes

Primary

MeasureTime frame
Fear of Disease Progression. Timepoint: Measurements will be conducted at three time points: before the intervention (baseline), immediately after the intervention completion (post-treatment), and three months after the intervention completion (3-month follow-up). Method of measurement: The individual's score on the Fear of Disease Progression Questionnaire (FoP-Q).;Perceived Stress. Timepoint: Measurements will be conducted at three time points: before the intervention (baseline), immediately after the intervention completion (post-treatment), and three months after the intervention completion (3-month follow-up). Method of measurement: The participant's score on the Cohen Perceived Stress Scale (PSS).;Intolerance of Uncertainty. Timepoint: Measurements will be conducted at three time points: before the intervention (baseline), immediately after the intervention completion (post-treatment), and three months after the intervention completion (3-month follow-up). Method of measurement: The respondent's Intolerance of Uncertainty Scale (IUS) score.

Secondary

MeasureTime frame
Depresion. Timepoint: Measurements will be conducted at three time points: before the intervention (baseline), immediately after the intervention completion (post-treatment), and three months after the intervention completion (3-month follow-up). Method of measurement: BDI Questionnaire score.;Anxiety. Timepoint: Measurements will be conducted at three time points: before the intervention (baseline), immediately after the intervention completion (post-treatment), and three months after the intervention completion (3-month follow-up). Method of measurement: BAI Questionnaire score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe karami

Zanjan University of Medical Sciences

eliikaramiii@gmail.com+98 992 061 7285

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026