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Investigating the effect of oral riboflavin on increasing corneal strength in Keratoconus patients

Investigating the effect of oral riboflavin on increasing corneal strength in Keratoconus patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250708066409N1
Enrollment
92
Registered
2025-07-30
Start date
2025-08-11
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

keratoconus. Other disorders of sclera and cornea in diseases classified elsewhere

Interventions

Intervention 1: Intervention group: Patients are given oral riboflavin (400 mg daily, 100 mg tablets twice a day, two tablets each time) for 6 months. Intervention 2: Control group: Control group: Pat

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 25 Years

Inclusion criteria

Inclusion criteria: 20-25 years old patients with non-progressive keratoconus that doesnt have indication for CXL.

Exclusion criteria

Exclusion criteria: History of surgery in the study eye (transplant, CXL) K-MAX greater than 60 diopters (measured with a pentacam device (Oculus Optikgerate GmbH, Wetzlar, Germany)) Presence of active liver or kidney disease Presence of stress lines in the examination

Design outcomes

Primary

MeasureTime frame
Kmax variable as an increase in topographic imaging. Timepoint: before, 3 months, and 6 months after the start of the intervention,. Method of measurement: Corneal topography devices, Pentacam, autorefractometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Ashtar

Mashhad University of Medical Sciences

Ashtarmr4011@mums.ac.ir+98 51 3833 5886

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026