Neonatal Hyperbilirubinemia. Neonatal jaundice from other and unspecified causes
Conditions
Interventions
Intervention 1: Intervention group: Preterm neonates will receive standard phototherapy with a white plastic cover placed around the phototherapy unit. The cover is made of glossy white plastic, 2 mm
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Neonates with a gestational age = 35 weeks Indication for phototherapy according to the Bhutani nomogram Diagnosis of non-hemolytic neonatal hyperbilirubinemia Parental consent for participation in the study
Exclusion criteria
Exclusion criteria: Neonates with major congenital anomalies Presence of hemolytic disease (e.g., ABO or Rh incompatibility) Use of drugs affecting bilirubin metabolism, such as phenobarbital Use of herbal remedies (e.g., jujube, shir-khesht, or similar traditional agents) Neonates suspected of having an infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in total serum bilirubin level before and after phototherapy. Timepoint: Before intervention (at admission), and at 12 hours, 24 hours, and at discharge after the start of phototherapy. Method of measurement: Total serum bilirubin will be measured using standard laboratory blood tests with a validated automated biochemical analyzer. Blood samples will be collected through venipuncture at specified time points. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of phototherapy (in hours). Timepoint: From the start of phototherapy to its discontinuation (measured in hours). Method of measurement: Duration of phototherapy will be measured by recording the start and end time of phototherapy in each patient’s medical chart. The total duration will be calculated in hours.;Rate of bilirubin reduction per hour. Timepoint: Calculated between each bilirubin measurement timepoint (e.g., 0–12h, 12–24h). Method of measurement: The rate of bilirubin reduction will be calculated by subtracting the initial serum bilirubin level from the level measured at subsequent time points, divided by the number of hours between measurements.;Side effects (hyperthermia, rash, dehydration). Timepoint: Every 6 hours during phototherapy. Method of measurement: Side effects will be monitored and recorded every 6 hours during phototherapy by trained nurses. Hyperthermia will be defined as axillary temperature > 37.5°C. Skin rash and signs of dehydration will be clinically assessed and documented. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Amirabbas Sharif
Kashan University of Medical Sciences
Outcome results
None listed