Investigating the effectiveness of umbilical cord blood serum on curing eye dryness

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250702066328N1

Enrollment

Registered

2025-12-29

Start date

2025-12-16

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye. Disorders of lacrimal system

Interventions

Intervention 1: Intervention Group:Patients in this group will receive eye drops prepared from diluted human umbilical cord blood serum in combination with standard artificial tears. The cord blood se

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with dry eyes for more than 3 months that do not improve with conventional treatment (such as artificial tears or ointments) Patients with dry eye who have a Type I Schirmer test of less than 5 mm Dry eye patients with Oxford test scores greater than stage 3

Exclusion criteria

Exclusion criteria: Age under 18 years Pregnancy Use of contact lenses History of ocular allergy, intraocular surgery, and/or refractive surgery within the past 6 months Anatomical changes of the eyelids and/or eyelashes Patients with infectious or transmissible diseases such as HBV, HCV, or HIV

Design outcomes

Primary

Measure	Time frame
Determining and comparing average visual acuity in dry eye treatment. Timepoint: At the beginning of the study and the first and third months after the start of the diluted fetal umbilical cord blood serum drip. Method of measurement: It was measured based on the LogMAR method (Logarithm of the minimum angle of resolution).;Determining and comparing the average dryness score in dry eye treatment. Timepoint: At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: It is determined based on the OSDI questionnaire score and recorded in the information form.;Corneal sensitivity. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: Corneal sensitivity.;Tear film break up time. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: tear film breakup time (Second).;The height of the lacrimal prism. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: Tear meniscus height is measured using slit lamp examination and recorded on the information form.;Blink frequency. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: It is determined based on blink rates (25%, 50%, 75% blinks, All lid closures, Extended lid closures, and Superextended lid closures) and recorded in the information form.	—

Measure

Time frame

Determining and comparing average visual acuity in dry eye treatment. Timepoint: At the beginning of the study and the first and third months after the start of the diluted fetal umbilical cord blood serum drip. Method of measurement: It was measured based on the LogMAR method (Logarithm of the minimum angle of resolution).;Determining and comparing the average dryness score in dry eye treatment. Timepoint: At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: It is determined based on the OSDI questionnaire score and recorded in the information form.;Corneal sensitivity. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: Corneal sensitivity.;Tear film break up time. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: tear film breakup time (Second).;The height of the lacrimal prism. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: Tear meniscus height is measured using slit lamp examination and recorded on the information form.;Blink frequency. Timepoint: ?At the beginning of the study and one month and three months after starting the use of diluted fetal cord blood serum. Method of measurement: It is determined based on blink rates (25%, 50%, 75% blinks, All lid closures, Extended lid closures, and Superextended lid closures) and recorded in the information form.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehraneh Jafari

Zahedan University of Medical Sciences

Mehranejafarimums@gmail.com54333372113

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026