recurrent implantation failure. Female infertility, unspecified
Conditions
Interventions
Intervention 1: Intervention Group: Group A will consist of 40 patients with recurrent implantation failure (RIF). From these patients, 20 milliliters of peripheral blood will be collected and placed
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: At least 3 previous unsuccessful IVF/ET treatments Age under 40 years BMI between 18 and 25 Regular and normal menstrual cycles for at least 3 consecutive months (cycle length between 25-35 days) No identified primary causes of infertility
Exclusion criteria
Exclusion criteria: Abnormal levels of thyroid hormones, FSH, LH, Estrogen, Progesterone, GH, Insulin, or Glucagon Positive antiphospholipid syndrome screening test Anatomical uterine abnormalities detected by ultrasound or hysteroscopy History of genetic disease or abnormal karyotype in the mother or father, or through cytological examinations Coagulation disorders or abnormal thrombophilia screening (Factor V Leiden, Prothrombin, Antithrombin III) Evidence of genital infection Identified underlying cause related to unsuccessful pregnancy Presence of tumors or other diseases with abnormal test results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy onset. Timepoint: 14 Days after Intervention. Method of measurement: lab test Bhcg. | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of treatment-related side effects, assessed through a designed questionnaire and specialist physician visits. Timepoint: days after intervention. Method of measurement: Investigator assessment.;The relationship between the occurrence of clinical pregnancy in patients with recurrent implantation failure (RIF) and the Th1/Th2 cell ratio. Timepoint: 14 days after intervention. Method of measurement: lab test.;The impact of endometrial thickness at the time of embryo transfer on treatment efficacy in the intervention group. Timepoint: 14 days after intervention. Method of measurement: Sonography.;The effect of the number of previous failed IVF attempts on the efficacy of treatment with hCG-treated PBMCs. Timepoint: 14 days after intervention. Method of measurement: analysis of data. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeid Taghiloo
Mazandaran University of Medical Sciences
Outcome results
None listed