Magnesium Supplementation and Its Effect on Kidney Stones

Evaluation of the Effect of Oral Magnesium Supplementation on the Recurrence Rate of Calcium Oxalate Stones

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250701066323N1

Enrollment

Registered

2025-08-10

Start date

2025-08-26

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oxalate kidney stones. Calculus of kidney

Interventions

Intervention 1: Intervention Group: Patients in this group will receive routine therapy consisting of potassium citrate and hydrochlorothiazide, in addition to magnesium oxide tablets (300 mg).The mag

Eligibility

Sex/Gender

All

Age

18 Years to 72 Years

Inclusion criteria

Inclusion criteria: Serum potassium level less than 5.5 mEq/L (K < 5.5) Serum magnesium level less than 2.5 mg/dL (Mg < 2.5) Confirmed previous diagnosis of calcium oxalate kidney stones Presence of kidney stone(s) smaller than 5 mm as confirmed by CT scan

Exclusion criteria

Exclusion criteria: Lack of patient consent to participate in the study Suffering from underlying diseases affecting metabolism or stone excretion (such as diabetes, malabsorption, hypertension, etc.) Use of medications that may interfere with magnesium, calcium, or kidney stone metabolism Pregnancy or Lactation

Design outcomes

Primary

Measure	Time frame
The recurrence rate of calcium oxalate stones. Timepoint: At the beginning of the study and 6 months after the start of the intervention. Method of measurement: To assess outcomes, 24-hour urine analysis will be performed using an automated biochemical analyzer (Hitachi 902, Roche Diagnostics), which allows precise measurement of citrate, oxalate, electrolytes, and other biochemical parameters. Additionally, renal and urinary tract ultrasonography will be conducted using a Mindray DC-70 ultrasound machine by an experienced radiologist.	—

Measure

Time frame

The recurrence rate of calcium oxalate stones. Timepoint: At the beginning of the study and 6 months after the start of the intervention. Method of measurement: To assess outcomes, 24-hour urine analysis will be performed using an automated biochemical analyzer (Hitachi 902, Roche Diagnostics), which allows precise measurement of citrate, oxalate, electrolytes, and other biochemical parameters. Additionally, renal and urinary tract ultrasonography will be conducted using a Mindray DC-70 ultrasound machine by an experienced radiologist.

—

Secondary

Measure	Time frame
Blood Magnesium. Timepoint: At the beginning of the study and 6 months after the start of the intervention. Method of measurement: Serum magnesium levels will be measured using an automated biochemical analyzer (Hitachi 902, Roche Diagnostics) based on the colorimetric spectrophotometric method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Masoud Moeinitaba

Kashan University of Medical Sciences

MoeiniTaba-M@kaums.ac.ir+98 31 5510 3105

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026