Laparoscopic cholecystectomy is one of the most common abdominal surgeries performed electively in patients with gallstones or chronic cholecystitis. Despite the advantages of this procedure over open surgery, hemodynamic changes resulting from anesthesia induction, intubation, and pneumoperitoneum can be problematic for the patient. In this study, the effect of oral gabapentin and clonidine on hemodynamic responses of elective patients undergoing this type of surgery was investigated. Chronic
Conditions
Interventions
Intervention 1: Intervention group 1: Group (G) received oral gabapentin capsules 300 mg from Mehrdaro Company two hours before anesthesia. Intervention 2: Second intervention group: Group (CL) receiv
Sponsors
Vice President for Research, Hormozgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-65 years who are candidates for laparoscopic cholecystectomy with ASA ?,? Patient satisfaction
Exclusion criteria
Exclusion criteria: People with uncontrolled systemic diseases (ASA>2) History of substance abuse Emergency patients Allergy to study drugs Current use of sedatives, hypnotics, or chronic pain relievers Patients who develop complications during laparoscopic cholecystectomy and require open surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate changes during laparoscopic cholecystectomy. Timepoint: Before pneumoperitoneum, immediately after pneumoperitoneum, then 3 minutes, 5 minutes every 10 minutes until the end of laparoscopic surgery. Method of measurement: Pulse oximeter device.;Systolic blood pressure changes during laparoscopic cholecystectomy immediately after pneumoperitoneum. Timepoint: Before pneumoperitoneum, immediately after pneumoperitoneum, then 3 minutes, 5 minutes every 10 minutes until the end of laparoscopic surgery. Method of measurement: Blood pressure cuff.;Changes in ambient oxygen saturation during laparoscopic cholecystectomy immediately after pneumoperitoneum. Timepoint: Before pneumoperitoneum, immediately after pneumoperitoneum, then 3 minutes, 5 minutes every 10 minutes until the end of laparoscopic surgery. Method of measurement: Pulse oximeter device.;Diastolic blood pressure changes during laparoscopic cholecystectomy immediately after pneumoperitoneum. Timepoint: Before pneumoperitoneum, immediately after pneumoperitoneum, then 3 minutes, 5 minutes every 10 minutes until the end of laparoscopic surgery?. Method of measurement: Blood pressure cuff.;Changes in mean arterial blood pressure during laparoscopic cholecystectomy immediately after pneumoperitoneum. Timepoint: Before pneumoperitoneum, immediately after pneumoperitoneum, then 3 minutes, 5 minutes every 10 minutes until the end of laparoscopic surgery?. Method of measurement: Blood pressure cuff. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Mehrdad
Bandare-abbas University of Medical Sciences
Outcome results
None listed