Basal Cell Carcinoma. Basal cell carcinoma of skin of unspecified parts of face
Conditions
Interventions
Intervention group: Intervention group: Methylene blue 0.5mg/ml solution and formulated ointment are applied topically on the patients BCC lesion every two days for a month and the lesion is photograp
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Informed and written consent of the patient to participate in the study. Diagnosis of basal cell carcinoma of the skin confirmed by pathology. Patient unwillingness to undergo surgery or inability to undergo surgery or inability to administer intralesional medical treatment such as interferon alpha or 5-FU. Age 18 years and older. Lesion size less than 2 cm. Superficial and nodular form of BCC Multiple lesions
Exclusion criteria
Exclusion criteria: Basal cell carcinoma of the skin of the morphea-like and nodular ulcerative type Pregnancy and lactation. History of serious drug-related complications. Failure to complete the course of treatment. Failure to refer for follow-up treatment. History of cardiovascular diseases. History of thromboembolic diseases. Radiotherapy treatment in the relevant area Contact with arsenic. Weak immunity. Presence of serious systemic disease. Having a history of allergy or sensitivity to methylene blue. Having a history of bleeding disorders or abnormal blood clotting. Having a history of severe skin disorders or inflammation in the treatment area
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome of Complete Wound Repair After 2 Months of Treatment Initiation Based on Dermoscopic Results and Clinical Repair. Timepoint: Methylene blue 0.5mg/ml solution and formulated ointment are applied topically to the lesion every two days for a month and the lesion is photographed. If the wound improves and shrinks, the same procedure is continued until complete healing, and if there is no improvement after one month, standard methylene blue photodynamic therapy is applied for another month. Method of measurement: Outcomes are evaluated by measuring changes in lesion size, examining tissue repair, clinical and dermoscopic imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome of the absence of ulcer recurrence after 6 months of patient follow-up. Timepoint: After the four stages of treatment, wound repair ointment will be applied to speed up the healing process. Method of measurement: Outcomes are evaluated by measuring changes in lesion size, examining tissue repair, clinical and dermoscopic imaging. Also, if the patient agrees, tissue sampling will be used to evaluate pathology. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Razmara
Mashhad University of Medical Sciences
Outcome results
None listed