Comparison of Preoperative Oral Gabapentin and Pregabalin for Reducing Acute and Chronic Postoperative Pain After Breast Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250630066304N2

Enrollment

Registered

2025-08-22

Start date

2025-09-23

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Operative Pain. Other chronic postprocedural pain

Interventions

Intervention 1: First Intervention group (Gabapentin). Intervention 2: Second Intervention group (Pregabalin).

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Patients with ASA class 1 and 2 Breast surgery candidates at Imam Khomeini Teaching and Therapeutic Hospital, Sari Informed consent to participate in the study Stable mental and cognitive status and absence of psychiatric disorders

Exclusion criteria

Exclusion criteria: History of chronic renal failure before surgery (mg/dl > 2) Liver disease (cirrhosis or liver failure) History of use of pregabalin or gabapentin History of allergy to pregabalin or gabapentin History of recent use of any opiates or alcohol Patients who require prolonged intubation after surgery for any reason

Design outcomes

Primary

Measure	Time frame
Pain intensity after surgery. Timepoint: The day of the surgery - 3 months later. Method of measurement: VAS Score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira Sobhani

Mazandaran University of Medical Sciences

Ssobhani1983@gmail.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026