Infection and inflammatory reaction due to internal joint prosthesis. Infection and inflammatory reaction due to internal joint prosthesis
Conditions
Interventions
Intervention 1: Control group: In the control group, patients will receive 1 gram (patients under 80 kg) or 2 grams (for patients over 80 kg) in 200 ml of saline as a short-term intravenous injection
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria include patients with advanced and symptomatic knee osteoarthritis, regardless of age, who are scheduled for elective total knee arthroplasty due to lack of response to conservative treatments (medication and physiotherapy).
Exclusion criteria
Exclusion criteria: Acute or emergency knee surgery history of knee infection history of previous knee surgery use of antibiotics within 3 days prior to the start of the study history of cephalosporin sensitivity failure to use antibiotics correctly in related subgroup due to missing dose or GI side effects history of uncontrolled underlying disease such as diabetes, which can lead to a weakened immune system Patients with a compromised immune system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical site, prosthesis and systemic infection. Timepoint: in 3 months following surgery. Method of measurement: clinical examination.;Range of motion. Timepoint: pre-operative / in 3 months following surgery. Method of measurement: goniometry.;Pain. Timepoint: pre-operative / in 3 months following surgery. Method of measurement: Visual analogue scale (VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Hosein Khajavi Rad
Mashhad University of Medical Sciences
Outcome results
None listed