People with mild cognitive impairment.
Conditions
Interventions
Intervention 1: Intervention group: Sesame seed dry extract contains bioactive compounds, including lignans, which may have beneficial effects on cognitive function. This extract is given to participa
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: People aged 50 to 75 years Written and informed consent after full education about the study objectives Montreal Assessment (MoCA) score 18 - 25 Clinical Dementia Rating Scale (CDR) score 0.5 BMI>23 and BMI<35 Ability to read and write Fluent in Persian Physical and mental ability to participate in studying and taking tests
Exclusion criteria
Exclusion criteria: History of stroke or other cerebrovascular disorders Diagnosis of Alzheimer's disease or dementia Presence of brain tumors or other structural brain damage Severe psychiatric disorders, such as major depression or bipolar disorder Epilepsy, mental retardation, Parkinson's, multiple sclerosis (MS), severe renal, hepatic, cardiac, blood malignancy, endocrine problems such as uncontrolled diabetes or severe hypo/hyperthyroidism, and major digestive problems Participants with pacemakers, intracranial metal objects, or a history of brain surgery, aneurysm clips, artificial heart valves, ear implants, metal parts or foreign bodies in the eyes, skin, or body Alcohol and drug abuse Taking medications that affect cognitive function, such as the benzodiazepine family (diazepam, lorazepam, alprazolam, etc.), anticholinergic drugs (amitriptyline, doxepin, oxybutynin, etc.), non-benzodiazepine hypnotics (zolpidem and zopiclone, etc.), opioid analgesics (morphine, oxycodone, hydrocodone, etc.), antipsychotic drugs (haloperidol, risperidone, and clozapine, etc.), and tricyclic antidepressants (imipramine, clomipramine, etc.) Consume sesame oil, olive oil, coconut oil, fish oil, and omega-3s due to their proven cognitive effects. Continuous consumption (more than 30 grams per week) of Ardeh and other sesame compounds such as halvah in the three months prior to the intervention Taking medications to enhance memory and concentration Continuous consumption, known allergy or sensitivity to sesame or its ingredients Participation in other clinical studies in the past 3 months Lack of adequate visual, auditory, and motor function to complete the tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Cambridge Automated Neuropsychological Test Battery (CANTAB) is a comprehensive computer-administered cognitive test. It consists of 25 items in the domains of visual memory, executive function, attention, verbal memory, decision-making and response control, and social cognition. We use three of these items in this study across three different domains. Timepoint: Cognitive tests and other parameters are measured at the beginning of the study (before the intervention begins) and after 12 weeks (end of the intervention). Method of measurement: CANTAB cognitive tests are measured using a touchscreen. | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MOCA), Clinical Dementia Rating (CDR), 15-item Depression Questionnaire (GDS-15), anthropometric indices. Timepoint: Everyone will be assessed at the beginning of the study (before the intervention) and after 12 weeks (end of the intervention). Method of measurement: Using the latest version of the Montreal Cognitive Test, the Clinical Dementia Rating Scale, the 15-item Depression Questionnaire, and anthropometric indices are also measured using scales and meters. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKian khosravi
Ahvaz University of Medical Sciences
Outcome results
None listed