The Effect of Partial Replacement of Dietary Bread Salt with Yeast Extract on Blood Pressure Control

Investigation the Effect of Partial Replacement of Dietary Bread Salt with Yeast Extract on Blood Pressure Control in Hypertensive Patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250625066256N1

Enrollment

122

Registered

2025-07-26

Start date

2025-08-23

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Essential (primary) hypertension

Interventions

Intervention 1: Intervention group: The intervention group will be given bread containing yeast extract, in which part of the regular salt has been replaced with yeast extract. The loaves are complete

the type of bread will be hidden from both researchers and participants. People must visit the study site weekly and receive their bread. Each person is given 14 loaves of bread (considering the consu

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Adults 18 to 75 years old People who have high blood pressure and have had their blood pressure diagnosed by a doctor are eligible to enter the study.

Exclusion criteria

Exclusion criteria: Pregnant and lactating women People with chronic diseases, including liver, kidney, lung, thyroid, and cancer Those who follow a special diet

Design outcomes

Primary

Measure	Time frame
Systolic and diastolic blood pressure. Timepoint: At the beginning and end of the study and every two weeks during the study. Method of measurement: sphygmomanometer.	—

Secondary

Measure	Time frame
Uric acid. Timepoint: Before and after the intervention. Method of measurement: uric acid photometric.;Fasting glucose. Timepoint: Before and after the intervention. Method of measurement: FBS photometric.;Creatinine. Timepoint: Before and after the intervention. Method of measurement: Creatinine photometric.;Urea. Timepoint: Before and after the intervention. Method of measurement: BUN photometric.;Serum lipid profile. Timepoint: Before and after the intervention. Method of measurement: lipid profile photometric.;Sodium in 24-hour urine. Timepoint: Before and after the intervention. Method of measurement: Na atomic absorption.;Potassium in 24-hour urine. Timepoint: Before and after the intervention. Method of measurement: K atomic absorption.;Creatinine in 24-hour urine. Timepoint: Before and after the intervention. Method of measurement: Creatinine atomic absorption.	—

Measure

Time frame

Uric acid. Timepoint: Before and after the intervention. Method of measurement: uric acid photometric.;Fasting glucose. Timepoint: Before and after the intervention. Method of measurement: FBS photometric.;Creatinine. Timepoint: Before and after the intervention. Method of measurement: Creatinine photometric.;Urea. Timepoint: Before and after the intervention. Method of measurement: BUN photometric.;Serum lipid profile. Timepoint: Before and after the intervention. Method of measurement: lipid profile photometric.;Sodium in 24-hour urine. Timepoint: Before and after the intervention. Method of measurement: Na atomic absorption.;Potassium in 24-hour urine. Timepoint: Before and after the intervention. Method of measurement: K atomic absorption.;Creatinine in 24-hour urine. Timepoint: Before and after the intervention. Method of measurement: Creatinine atomic absorption.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarima chaichi khorsand

Shiraz University of Medical Sciences

FarimaKhorsand.fk@gmail.com+98 13 4454 3238

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026