Necrotizing Enterocolitis. Necrotizing enterocolitis of newborn
Conditions
Interventions
Intervention 1: Intervention group: Neonates in this group will receive oral Docosahexaenoic Acid (DHA) syrup (Brand: Advancis Omega Mousse, Pharmodietica, Portugal). The concentration is 129 mg of DH
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
No minimum to 238 Days
Inclusion criteria
Inclusion criteria: Born at a gestational age of less than 34 weeks Admitted to the Neonatal Intensive Care Unit (NICU) Able to tolerate oral feeding without significant gastrointestinal complications
Exclusion criteria
Exclusion criteria: Chromosomal abnormalities Critical illness requiring extensive resuscitation (eg, low Apgar scores, cardiovascular shock, unstable hemodynamics) Sepsis Life-threatening infections Intraventricular hemorrhage (IVH) grade III or higher Major congenital heart defects Suspected gastrointestinal atresia Malrotation Any gastrointestinal condition requiring surgical intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of necrotizing enterocolitis according to modified Bell's criteria. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: using modified Bell's criteria based on clinical, laboratory, and radiographic findings. | — |
Secondary
| Measure | Time frame |
|---|---|
| Feeding intolerance. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: clinical examination.;Abdominal distension. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: clinical examination.;Thrombocytopenia. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: Laboratory evaluation will be performed using the electrical impedance method with a Mindray brand cell counter.;Abdominal wall discoloration. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: clinical examination.;Abdominal tenderness. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: clinical examination.;Neutropenia. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: Laboratory evaluation will be performed using the electrical impedance method with a Mindray brand cell counter.;Metabolic acidosis. Timepoint: Before the intervention, daily during the intervention, and one week after the completion of the intervention. Method of measurement: using blood gas analyzer Radiometer brand. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAynaz Parvaz
Kerman University of Medical Sciences
Outcome results
None listed