Evaluation the effectiveness of safflower oil-clobetasol in the treatment of mild eczema

Preparation and Evaluation of Paraben-Free Herbal-Chemical Cream in Patients with Mild Eczema; a randomized controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250625066252N1

Enrollment

Registered

2025-11-20

Start date

2025-07-23

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild eczema. Other atopic dermatitis

Interventions

Intervention 1: Intervention group: Intervention group: 10% safflower oil cream, made by Isfahan University of Medical Science, School of Pharmacy,twice a day, for 28 days. Intervention 2: Control gro

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mild eczema in the areas of limbs and trunk; Mild eczema is defined as Involvement of a maximum of 10% of the body surface area (BSA).

Exclusion criteria

Exclusion criteria: Incidence of Facial or scalp eczema Receiving systemic anti-eczema treatment and phototherapy during last month Receiving topical anti-eczema treatment during last two weeks Autoimmune disorders Incidence of other chronic skin disorders (pemphigus, dermatitis, lichen planus) Infection in the lesion Pregnancy Lactation

Design outcomes

Primary

Measure	Time frame
Change in SCORAD score at the end of the intervention. Timepoint: Before the intervention, 28 days after the start of intervention. Method of measurement: In the aforementioned index, the level of body involvement is determined in terms of percentage (A), the severity score of redness, edema, discharge, signs of itching, skin thickening, and dryness (B), and the patient's assessment of itching severity and sleep disturbance based on a visual analogue scale (VAS) from 1 to 10 (C) and using the following formula: Total SCORAD score = A/5 + 7B/2 + C.	—

Measure

Time frame

Change in SCORAD score at the end of the intervention. Timepoint: Before the intervention, 28 days after the start of intervention. Method of measurement: In the aforementioned index, the level of body involvement is determined in terms of percentage (A), the severity score of redness, edema, discharge, signs of itching, skin thickening, and dryness (B), and the patient's assessment of itching severity and sleep disturbance based on a visual analogue scale (VAS) from 1 to 10 (C) and using the following formula: Total SCORAD score = A/5 + 7B/2 + C.

—

Secondary

Measure	Time frame
Percentage of people with complete recovery of eczema at the end of the intervention. Timepoint: Before the intervention, 28 days after the start of intervention. Method of measurement: Observation.;The time required for complete recovery of eczema during the intervention. Timepoint: Before the intervention, 28 days after the start of intervention. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ladan Dayani

Esfahan University of Medical Sciences

l.dayani@pharm.mui.ac.ir+98 31 3792 7067

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026